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This study forms the basis of future investigations into molecular mechanisms regulating feeding behaviors and metabolic processes that contribute to the weight loss effects of GLP-1R agonists
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Native GLP-1, however, proved impractical as a therapeutic agent due to its extremely short plasma half-life of approximately two minutes, the result of rapid degradation by the ubiquitous enzyme dipeptidyl peptidase-4 (DPP-4) and renal clearance
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