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Moreover, no serious adverse events were recorded in the tirzepatide group, although there was a single case of acute myocardial infarction in the placebo group
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37 , 40 Concomitantly, circulating pro‐inflammatory cytokines such as tumour necrosis factor‐α (TNF‐α), interleukin‐6 (IL‐6), and interleukin‐1β (IL‐1β) can cross the blood–brain barrier (BBB) or alter its integrity, thereby promoting microglial activation and astrocytic reactivity
