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Pharmacological use of GLP-1 analogs to treat obesity and diabetes The exogenous supplementation of native hormones, commonly purified from tissue homogenates, has led to numerous, seminal discoveries, most prominently the identification of insulin in 1921 [875] followed by the discovery of glucagon in 1923 [3]

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268 When activated, the vagus nerve can reduce the contraction of the stomach, thereby slowing down food emptying