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The drug significantly slowed biological processes associated with the risk of all‑cause mortality and age-related disease, as measured by the PCGrimAge epigenetic clock
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30 Also, the onset of acute pancreatitis occurred after 12 months in the LEADER trial and after more than five to six months in the SCALE trial, indicating that the likelihood of developing pancreatitis was influenced more by the rate and degree of weight loss than the drug itself
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