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However: The meta-analysis did highlight some data showing that “Tirzepatide demonstrated superior effectiveness over semaglutide [in reducing HbA1c levels].” In short, individual studies have shown some strong data backing tirzepatide as a more robust weight management drug than semaglutide—but the jury’s still out, and we need to wait for more data overall

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Nonclinical Toxicology 13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility In a 2-year carcinogenicity study in CD-1 mice, subcutaneous doses of 0.3, 1 and 3 mg/kg/day [2-, 11-, and 30-fold the maximum recommended human dose (MRHD) of 2 mg/week, based on AUC] were administered to the males, and 0.1, 0.3 and 1 mg/kg/day (1-, 2-, and 7-fold MRHD) were administered to the females