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More than 6 million patients in the US initiated GLP-1 use between 2021 and 2025. The proportion of prescriptions without documented clinical indications rose steadily over that time, reaching roughly 0.74% by
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They are also prescribed for patients who are overweight, i.e ., those with a BMI of greater than 27, and who also have one weight-related condition, such as hypertension, hyperlipidemia or sleep apnea
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