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Key distinctions in the evidence: Tesamorelin: licensed in the US, narrowly indicated, established in HIV-related lipodystrophy, with effects that reverse on stopping treatment Retatrutide: investigational, broader metabolic potential, not yet approved anywhere globally Patients and clinicians should interpret early-phase data for retatrutide with appropriate caution

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It was clear that glucagon and the glucagon-like material were distinct entities, and immunohistochemical studies revealed that intestinal cells that were positive for the glucagon-like material had a different morphology from glucagon secreting α-cells