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Observational evidence further supports a context-dependent effect of metformin, as data from the National Alzheimer’s Coordinating Center database found that metformin use was associated with improved memory performance, but this benefit was not observed in APOE-ε4 carriers 90 , suggesting that metformin may be protective in individuals with DM2 but not in those with certain genetic predisposition factors for AD, such as APOE-ε4, which is the strongest genetic risk factor for sporadic AD 91
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Novo also launched its “Check Before You Inject” campaign to educate patients on the risks associated with unregulated formulations
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