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Cells carry more receptors than the machinery downstream can use, and the effect can run near its ceiling while occupancy is still low (the spare-receptor effect).⁴ For retatrutide this gap is largest at the GLP-1 receptor, where the concentration that half-fills the appetite signal is roughly nine times lower than the concentration that half-fills the receptor itself
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If a brain region mediates the anorectic effect of GLP-1R agonists, its activity should be modulated by liraglutide
