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While liraglutide- and PBS-treated SKO mice displayed comparable density of β cell area as a proportion of pancreatic area ( Figure 4C ), liraglutide treatment significantly increased pancreas weight in female SKO mice leading to an increase in total β cell mass per animal when normalised to body weight ( Figures 4D, E )

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The mechanism isn't dependent on weight loss itself—it's a direct pharmacological effect that appears quickly in the brain's appetite centers