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2 Psychotropic medication-induced metabolomic disturbances and insulin resistance 2.1 Clinical Spectrum and drug-specific liability Individuals with mental illness, including schizophrenia, bipolar disorder, and major depressive disorder, experience markedly increased premature mortality, with life expectancy shortened by up to 20 years and mortality rates approximately 2.0–3.5 times that of the general population (5, 14)
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